3/29/2024 0 Comments The brain 9![]() ![]() Conclusionsįor the large molecules of interest in neuropathology, bulk flow may be an important mechanism of interstitial transport. Simulations provide an upper limit for superficial convective velocity magnitude (approximately \(v\) = 50 μm min −1), a useful finding for researchers developing techniques to measure interstitial bulk flow. ![]() The simulations show (1) convective flow in the interstitium potentially of a similar magnitude to diffusive transport for molecules of interest and (2) exchange between the interstitium and perivascular space, whereby fluid and solutes may enter or exit the interstitium, are consistent with the experimental data. In this work, we compare a large body of published experimental data for transport in the brain to simulations of purely diffusive transport and simulations of combined convective and diffusive transport in the brain interstitium, incorporating current theories of perivascular influx and efflux. Here we describe a tool developed to aid in investigation of interstitial transport mechanisms, especially the potential for convection (or bulk flow) and its relevance to interstitial solute transport, for which there is conflicting evidence. Mathematical modelling verified using available experimental data offers a powerful tool for investigating hypotheses regarding extracellular transport of molecules in brain tissue. Despite advances in in vivo imaging and experimental techniques, the nature of transport mechanisms in the brain remain elusive. ![]()
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